| Fusion of Utmost Precision and Fine Mechanism
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The latest advances in IVF (In Vitro Fertilization) have led to the use of ICSI (Intracytoplasmic Sperm Injection) as a remedy for male infertility. To address these advances, Nikon and Narishige, a company renowned in the field of IVF, have collaborated to greatly improve the NT-88 series.
The new NT-88-V3 series delivers the microscopic and highly precise specimen micromanipulation required in IVF experiments, especially for ICSI, and other cutting-edge researches such as stem cells application, transgenics and electrophysiology.
With easy operation and unsurpassed level of precision, the NT-88-V3 is the outstanding solution for researchers involved in IVF exploration.
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◈ Size is greatly reduced as the 3D motor-driven coarse control micromanipulator and 3D hydraulic fine-- micromanipulator are combined in a single unit.
◈ Assembly of the micromanipulator is fast and easy due to the extremely stable, one-piece mounting-- adapter.
◈ Wide varieties of microinjectors for holding or injecting specimens depending on use.
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| Oil-hydraulic Micromanipulators
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| ■ 3D Hydraulic Micromanipulator NT-88-V3 |
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Combined 3D motor-driven coarse control micromanipulator and the 3D hydraulic fine micromanipulator realize remarkably compact and stable design.
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Less than half the size of a conventional model-minimal- length tubes and cords-the manipulator fits easily into- the incubator.
Closer-to-the-center settings are possible, while - reduced distance from manipulator mount to- microelectrode tip increases stability.
X-axis control knobs are located symmetrically on- opposite sides of the joystick to eliminate left side/right- side positioning problems.
10mm X-Y operating range provides versatility in - manipulation at lower magnifications.
A “resume” feature returns the pipette to the original - position after the pipette has been raised for quicker,- easier Petri dish changes.
The universal joint is outfitted with an angle gauge,- which ensures accurate-angle operation. The forward-- mounted return mechanism facilitates Petri dish- changing.
Permits one-touch installation on an inverted - microscope. |
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| Hydraulic Fine Micromanipulator |
Working range |
Control Knob operation |
Max.10mm |
Joystick operation |
Max. 2mm |
Displacement by Control Knob rotation |
Full turn of knob |
250μm |
Minimum graduation |
2μm |
| Motorized Coarse Manipulator |
Working range |
Max. 22mm |
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| ■ 3D Hydraulic Micromanipulator (Single-hand type) NT-88-V3SH |
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Suitable for experiments that do not require the holding side’s pipette, such as the microinjection or microdissection to an adherent cell.
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| ■ 3D Hydraulic Micromanipulator (Manual Single-hand type) NT-88-V3MSH |
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A manual 3D coarse positioning manipulator allows you to quickly move the micro-pipette to the ideal position. And the compact design allows you to position it closer to you with the control knob in easy reach.
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| ■ Universal Joint UJ-V3 |
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Universal Joint UJ-V3 allows the pipette holder to be moved in a single direction. The angle can be adjusted for both vertical and horizontal directions via two separate control knobs. The forwardmounted return mechanism facilitates changing the petri dish while the built-in angle gauge ensures accurate-angle operation. Moreover, because the UJ-V3 is mountable from above, unlike the conventional type, attachment and removal is much easier.
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| ■ Oil-type Microinjector IM-9B / Pneumatic InjectorIM-9C |
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These injectors provide smoother and more stable maneuverability by applying a new mechanism to minimize backlashes. Also, its 53mm working distance, large-volume syringe and just-the-rightsize control knob with graduated scales all contribute to easy control of the injection. The IM-9B has a finely-ground metal syringe for smoother movement, while its new tube connector with a multi-purpose valve makes for easier filling of oil without generating air bubbles.
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IM-9B |
IM-9C |
| Movement distance |
Movement range |
53mm |
53mm |
Full rotation of knob |
500μm |
6mm |
Minimum graduation |
10μm |
120μm |
| Control value
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Full rotation of knob |
10μl |
480μl |
Minimum graduation |
0.2μl |
9.6μl |
Syringe |
1.1cc metal type |
4.2cc glass type |
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| Micromanipulators for electro-physiology applications
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| ■ 3D Water-Hydraulic Micromanipulator MHW-3 |
The MHW-3 features minimized drift due to temperature changes, a scale increment as small as 0.2μm, and a fine control manipulation with a one-to-five moving ratio. Also, because Teflon tubes are secured to the microscope main body, vibration of the tip of the micropipettes has been eliminated, resulting in stable micromanipulation.
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| Movement range
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Fine 2mm (X, Y and Z axes), coarse 30mm (X, Y and Z axes) |
| Full rotation of knob
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50μm |
| Minimum graduation
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Fine 0.2μm |
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| ■ 3D Water-Hydraulic Micromanipulator MWO-3 |
The MWO-3 features a cutting-edge, hydraulic double-cartridge mechanism to minimize drifts caused by temperature changes. This design ensures injections with a constant pressure for stable operation that is free from drift, vibration, and electromagnetic disturbances.
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| Movement range
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Fine 2mm (X, Y and Z axes), coarse 30mm (X, Y and Z axes) |
| Full rotation of knob |
Fine 50μm, coarse approx. 4mm |
| Minimum graduation |
Fine 0.2μm |
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| ■ Manual 3D Micromanipulator NMN-21/25 |
The NMN-21 and -25 are designed for drift-free operation, making them ideal for delicate, patch-clamp research. The unit has no hydraulic system nor spring mechanism and its unique double-slider structure minimizes vibrations transmitted from the operator’s hand to the tip of the pipette via the control knob. The unit’s motor-less and actuator-less design also eliminates electromagnetic disturbances. The NMN-25 features a compact, space-saving design without a scale.
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NMN-21
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NMN-25
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| Movement range
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Fine 6mm (X, Y and Z axes),coarse 15mm (X, Y and Z axes) |
Fine 6mm (X axis),10mm (Y axis), 6mm (Z axis);coarse 15mm (X axis),10mm (Y axis), 15mm (Z axis) |
| Full rotation of knob |
Fine 250μm,coarse approx. 4mm |
Fine 250μm (X and Z axes),292μm (Y axis) |
| Minimum graduation |
Fine 1μm |
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